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If tizanidine therapy is to be discontinued, dosage of the drug should be decreased gradually, particularly in patients who have been receiving high dosages for prolonged periods, to minimize the risk of withdrawal and rebound symptoms.
Although the pharmacokinetics of tizanidine have not been evaluated in patients zanaflex 4mg tab hepatic impairment, the drug undergoes extensive first-pass metabolism in the liver.In elderly patients with renal zanaflex 4mg tab creatinine clearance 25 mL/min tizanidine clearance is reduced by more than 50% compared to healthy elderly subjects; this would be expected to lead to a longer duration of clinical effect.
During titration, the individual doses should be reduced.
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Ann Intern Med. 2003 Jun. 871-81. Medline.Reviews that appear to be created by zanaflex 4mg uses with a vested interest in the medication will not be published. As reviews and ratings are subjective and self-reported, this information should not be used as the basis for any statistical analysis or scientific studies.
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