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Pentoxifyllin (Pentoxil) generic is a xanthine derivative, prescribed for intermittent claudication (pain, cramping, numbness, or weakness in the foot, hip, thigh, or buttocks) due to poor blood circulation. Pentoxifylline pack 20 mg 10 amount of packaging.

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Clinical data
Pronunciation/ ˌ p ɛ n t ɒ k ˈ s ɪ f ɪ l iː n, - ɪ n /
Trade namesMany names worldwide [1]
License dataUS   FDA: Pentoxifylline
Pregnancy categoryAU: B1 US: C (Risk not ruled out)
Routes of administrationBy mouth
ATC codeC04AD03 ( WHO )
Legal status
Legal statusAU: S4 (Prescription only) CA : ℞-only UK: POM (Prescription only) US: ℞-only
Pharmacokinetic data
Bioavailability10–30% [3]
MetabolismHepatic and via erythrocytes
Elimination half-life0.4–0.8 hours (1–1.6 hours for active metabolite) [3]
ExcretionUrine (95%), faeces (<4%) [3]

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The blood pressure response in cats and rabbits after epinephrine was slightly inhibited by pentoxifylline. The i.n Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

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Technology Assessment Report commissioned by the NIHR HTA Programme on trental mechanism of action of the National Institute for Health and Clinical Excellence 2010. A systematic trental mechanism of action and economic evaluation of cilostazol, naftidrofuryl oxalate, pentoxifylline and inositol nicotinate for the treatment of intermittent claudication in people with peripheral arterial disease.Blood pressure: People with low blood pressure may be more sensitive to side effects with the use of this medication.

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In rabbits pentoxifylline 2-10 mg/kg/i.Garcia-Saenz-de-Sicilia M, Duvoor C, Altamirano J, et al. A day-4 Lille Model predicts response to corticosteroids and mortality in severe alcoholic hepatitis.

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