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Nature. 2020 Jul 8.Microperimetry and adaptive optics are undergoing studies to confirm their usefulness in hydroxychloroquine toxicity screening. Clinically, this manifests as a bulls-eye maculopathy, although these fundus changes are evident only in the later stages of disease Figure 1 The mechanism of toxicity is unknown but is thought to be due to accumulation of the medication in the retinal pigment epithelium RPE leading to subsequent RPE degeneration.

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Not all submitted comments are published. Please see our commenting policy for details.Doses and duration of hydroxychloroquine or azithromycin use were not specified. All patients also received standard supportive management for.

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