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Olanzapine
Clinical data
Trade namesZyprexa, others [1]
AHFS/Drugs.comMonograph
MedlinePlusa601213
License dataEU  EMA:  by INN, US   FDA: Olanzapine
Pregnancy categoryAU: C US: C (Risk not ruled out)
Routes of administrationBy mouth, intramuscular injection
ATC codeN05AH03 ( WHO )
Legal status
Legal statusAU: S4 (Prescription only) CA : ℞-only NZ : Prescription medicine, UK: POM (Prescription only) US: ℞-only
Pharmacokinetic data
Bioavailability60-65% [2] [3] [4]
Protein binding93% [5]
MetabolismLiver (direct glucuronidation and CYP1A2 mediated oxidation)
Elimination half-life33 hours, 51.8 hours (elderly) [5]
ExcretionUrine (57%; 7% as unchanged drug), faeces (30%) [5] [6]

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