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A variety of ECG abnormalities were seen in this patient with a history of bundle branch block, including sinus bradycardia and varying degrees of AV block.Although the hypotensive effect of nifedipine is modest and well tolerated in most patients receiving the drug for angina, excessive and poorly tolerated hypotension occurs occasionally in such patients.

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In addition, since candesartan is not substantially metabolized by the CYP isoenzyme system, no substantial drug interaction has been reported in individuals receiving nifedipine concomitantly with candesartan. Concomitant use of nifedipine with ketoconazole, itraconazole, or fluconazole may affect the can nifedipine cause swelling in feet of nifedipine, possibly secondary to the inhibition of the CYP3A can nifedipine cause swelling in feet, and increased exposure of nifedipine may occur.A reversible reduction in the ability of human sperm to bind to and fertilize an ovum in vitro has been reported in a limited number of infertile men who were receiving usual dosages of nifedipine when the sperm was obtained.

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WebMD does not endorse any specific product, service, or treatment. Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.Patients were instructed to apply the ointment circumferentially 1 cm inside the anus, near the internal anal sphincter, every 8 h for 8 wk.

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The mechanism of this effect is not established.Concomitant oral administration of 1, -dihydropyridine-derivative calcium-channel blocking agents e. nifedipine with grapefruit juice usually should be avoided since potentially clinically important increases in hemodynamic effects may result.

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